America's shocking secret: Pictures that show how U.S. experimented on its own disabled citizens and prison inmates
Such experiments included giving hepatitis to mental patients in Connecticut, squirting a pandemic flu virus up the noses of prisoners in Maryland, and injecting cancer cells into chronically ill people at a New York hospital.
Much of this horrific history is 40 to 80 years old, but it is the backdrop for a meeting in Washington this week by a presidential bioethics commission.
Prison 'volunteers': In this 1966 picture, medical administrator Solomon McBride questions a clearly marked subject at Holmesburg Prison, Philadelphia. Questions have been rasied about whether inmates were coerced
U.S. officials also acknowledged there had been dozens of similar experiments in America - studies that often involved making healthy people sick.
A review by the Associated Press of medical journal reports and decades-old press clippings found more than 40 such studies.
Captive guinea pigs: In 1945, army doctors exposed inmates to malaria-carrying mosquitoes in the malaria ward at Stateville Penitentiary in Crest Hill, Illinois. Prisoners were enlisted to help the war effort
It echoes the deadly and meritless experiments conducted on Jewish concentration camp detainees at the hands of Nazi doctors.
Arthur Caplan, director of the University of Pennsylvania's Center for Bioethics, said: 'When you give somebody a disease - even by the standards of their time - you really cross the key ethical norm of the profession.'
Most of the recently revealed studies, from the 1940s to the 1960s, apparently were never covered by news media. Others were reported at the time but the focus was on the promise of enduring new cures, while glossing over how test subjects were treated.
Infect and observe: An army doctor watches as malaria-carrying mosquitoes bite the stomach of inmate Richard Knickerbockers, serving 10 to 14 years, in Stateville in 1945
Many prominent researchers felt it was legitimate to experiment on people who did not have full rights in society - people like prisoners, mental patients or the poor blacks.
Laura Stark, a Wesleyan University assistant professor of science in
society - who is writing a book about past federal medical experiments - said: 'There was definitely a sense - that we don't have today - that sacrifice for the nation was important.'
Though people in the studies were usually described as volunteers, historians and ethicists have questioned how well these people understood what was to be done to them and why, or whether they were coerced.
Prisoners have long been victimised for the sake of science. In 1915, the U.S. government's Dr Joseph Goldberger - today remembered as a public health hero - recruited Mississippi inmates to go on special rations to prove his theory that the painful illness pellagra was caused by a dietary deficiency (The men were offered pardons for their participation).
Survivor: Edward Anthony was experimented on while he was an inmate at Philadelphia's Holmesburg Prison. Shocking as it is today, doctors at the time did not find the experiments unethical
But studies using prisoners were uncommon in the first few decades of the 20th century, and were usually performed by researchers considered eccentric even by the standards of the day.
One was Dr LL Stanley, resident physician at San Quentin prison in California, who around 1920 attempted to treat older, 'devitalized men' by implanting in them testicles from livestock and from recently executed convicts.
One long-winded but otherwise cheery 1919 report in the Washington Post began: 'Enter San Quentin penitentiary in the role of the Fountain of Youth - an institution where the years are made to roll back for men of failing mentality and vitality and where the spring is restored to the step, wit to the brain, vigor to the muscles and ambition to the spirit. All this has been done, is being done... by a surgeon with a scalpel.'
SHOCKING CATALOGUE OF MEDICAL STUDIES BY AMERICA... ON AMERICA
The AP review of past research found:
1) A federally funded study begun in 1942 injected experimental flu
vaccine in male patients at a state insane asylum in Ypsilanti,
Michigan, then exposed them to flu several months later.It was
co-authored by Dr Jonas Salk, who a decade later would become famous as
inventor of the polio vaccine.
Some of the men weren't able to describe their symptoms, raising serious
questions about how well they understood what was being done to them.2) In federally funded studies in the 1940s, noted researcher Dr W Paul
Havens Jnr exposed men to hepatitis in a series of experiments,
including one using patients from mental institutions in Middletown and
Norwich, Connecticut.Dr Havens, a World Health Organization expert on viral diseases, was one
of the first scientists to differentiate types of hepatitis and their
causes.3) Researchers in the mid-1940s studied the transmission of a deadly
stomach bug by having young men swallow unfiltered faecal matter.
The study was conducted at the New York State Vocational Institution, a
reformatory prison in West Coxsackie.
The point was to see how well the disease spread through ingestion. The
study doesn't explain if the men were rewarded for this awful task.4) A University of Minnesota study in the late 1940s injected 11 public
service employee volunteers with malaria, then starved them for five
days. Some were also subjected to hard labour. Then they were treated
for malarial fevers with quinine sulfate.One of the authors was Ancel Keys, a noted dietary scientist who
developed K-rations for the military and the Mediterranean diet for the
public.5) For a study in 1957, when the Asian flu pandemic was spreading,
federal researchers sprayed the virus in the noses of 23 inmates at
Patuxent prison in Jessup, Md., to compare their reactions to those of
32 virus-exposed inmates who had been given a new vaccine.6) Government researchers in the 1950s tried to infect about two dozen
volunteering prison inmates with gonorrhoea using two different methods
in an experiment at a federal prison in Atlanta. But the researchers
noted their methods weren't comparable to how men normally got infected -
by having sex with an infected partner. Too late for the men they had
already infected.
The children were intentionally given hepatitis orally and by injection to see if they could then be cured with gamma globulin.
Holmesburg Prison in Philadelphia made extensive use of inmates for medical experiments. Some of the victims are still around to talk about it.
Edward Anthony, featured in a book about the studies, says he agreed to have a layer of skin peeled off his back, which was coated with searing chemicals to test a drug. He did that for money to buy cigarettes in prison.
He spoke of his reaction to the experiment, saying: 'I said "Oh my God, my back is on fire! Take this ... off me".'
The government responded with reforms. Among them: The U.S. Bureau of Prisons in the mid-1970s effectively excluded all research by drug companies and other outside agencies within federal prisons.
Criminal experiments: Experiments by Dr Josef Mengele (second left) and others like him were internationally condemned as war crimes for their lack of merit
As the supply of prisoners and mental patients dried up, researchers looked to other countries.
It made sense. Clinical trials could be done more cheaply and with fewer rules. And it was easy to find patients who were taking no medication, a factor that can complicate tests of other drugs.
Additional sets of ethical guidelines have been enacted, and few believe that another Guatemala study could happen today.
U.S. health officials argued the study would answer questions about AZT's use in the developing world.
The other study, by Pfizer, gave an antibiotic named Trovan to children with meningitis in Nigeria, although there were doubts about its effectiveness for that disease.
Critics blamed the experiment for the deaths of 11 children and the disabling of scores of others.
The issue of American-led foreign studies was still being debated when, last October, the Guatemala study came to light.
In the 1946-48 study, American scientists infected prisoners and patients in a mental hospital in Guatemala with syphilis, apparently to test whether penicillin could prevent some sexually transmitted disease. The study came up with no useful information and was hidden for decades.
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